Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions
نویسندگان
چکیده
منابع مشابه
Srinivas 6 α - Crystallins , small heat shock proteins with diverse functions in cell survival and stress tolerance
α-Crystallin, a multimeric protein, composed of αAand αB-crystallin subunits is abundantly present in the eye lens. Both the crystallin subunits have also been found in other tissues and exhibit sequence homology with small heat shock proteins. The expression of αB-crystallin is induced under heat and other stresses and in several neurodegenerative diseases. As a member of the small heat shock ...
متن کاملHDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
متن کاملThe Relationship between the Expression of Small Heat-Shock Proteins and Suppression of OCT4B1
Background: OCT4B1, a variant of OCT4, is expressed in both cancer cells and tissues. This variant has a main role in the regulation of both apoptotic and stress (heat-shock proteins) pathways. The aim of this study was to investigate the effects of OCT4B1 silencing on the expression of small heat-shock proteins (sHSPs)in three human tumor cell lines. Methods:...
متن کاملHeat shock proteins: the search for functions
Not so long ago, in the olden (golden ?) days, scientists interested in the biochemistry and cell biology of proteins attempted to explain an enzyme's catalytic and regulatory functions and the cytoskeleton's properties in terms of protein structure. But SDS PAGE, monoclonal antibodies, and cDNA libraries (nucleic acid sequences reverse transcribed from mRNAs and inserted into the genomes of ba...
متن کاملMultiple small heat shock proteins in rhizobia.
Seven genes coding for small heat shock proteins (sHsps) in Bradyrhizobium japonicum have been identified. They are organized in five operons that are coordinately regulated by ROSE, a negatively cis-acting DNA element. The deduced sHsps can be divided into two separate classes: class A, consisting of proteins that show similarity to Escherichia coli IbpA and IbpB, and class B, whose members di...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Biochemical Sciences
سال: 2012
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2011.11.005